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The researchers claim that this is the first time that a causal connection between migraine and major depression has been established that results from bidirectional influences. This means that each disorder increases the risk for first onset of the other. In other words, having depression predisposes one to migraine, and vice versa. This undermines the idea that the connection is psychological - an explanation that would be plausible only if the researchers had found a one-directional effect from migraine to depression. The researchers concluded that there is no simple explanation for the migraine/depression connection and that it is probably biochemical in nature, indicating that supplementation is a plausible solution.
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