ethoxybenzaldehyde, and the heat will not be far behind. Further chemical supply problems arise from this method's use of large amounts of
phenylacetone
anhydrous ether or THF in the LiAlHj reduction. This too will be duly noted by the heat, especially in combination with buying LiAlHt. A much more low-profile synthetic route is possible using calamus oil as the raw material. A couple of patents granted in the late 80s have completely changed the field of psychedelic amphetamine manufacture from the way Dr. Shulgin knew it during his days of cooking in the 60s. Previous to the publication of these patents, the Knoevenagel condensation of benzaldehydes to Jelly It It Is Take And Royal And Ok yield the nitroalkene, followed by the reduction of the nitroalkene to the amphetamine, was far superior to an alternative route making use of the common essential oils. Many essential oils have as major components substituted allylbenzenes. For example, sassafras oil is 80-90% safrole: The alternative route was to take this substituted allylbenzene, move the double bond to the propenyl position by heating with anhydrous alcoholic KOH, yielding in the case of safrole, isosafrole. Then a messy, tedious and low-yield reaction was used to convert this propenylbenzene to the corresponding phenylacetone. All we veteran speed cooks love phenylacetones, because they offer the cleanest and best route to the amphetamines, but the old-fashioned method of 12 Studies On The Production OfTMA-2 79 converting propenylbenzenes to phenylacetones made this route impractical: My khasiat royal gingko own khasiat royal gingko experience with this reaction dates to the early 80s, when I decided to torment myself by trying it. Detailed cooking procedures using it can be found in Pikhal under MDMA. My experience with the KOH isomerization was that the conversion of safrole to isosafrole went cleanly at about 100% yield, as long as traces of moisture were excluded from the reaction. The conversion of isosafrole to methylenedioxy-phenylacetone is another matter.The yields are low, a lot of work is required because the formic acid and hydrogen peroxide must be removed from the reaction mixture under a vacuum before final treatment with sulfuric acid solution to yield the phenylacetone, and these vapors corrode the aspirator supplying the vacuum. This method stinks! Two patents dating to the late 80s, and to a lesser extent a journal article dating back to 1970, have turned the situation around. The first patent I will cite is US patent 4,638,094, titled "A Process for Producing Phenylacetones." This patent reveals, using many different examples over the course of 36 pages, the best general method for converting allylbenzenes to the corresponding phenylacetone in very high yields. This procedure reacts the allylbenzene phenylacetone (for example safrole, as obtained in pure form by vacuum distilling sassafras oil) with methylnitrite in methanol solution containing water and a palladium catalyst to yield the phenylacetone. The palladium catalys
khasiat magic mushroom @ 2/23/2012 1:17:37 AM: